Publikationen der letzten 5 Jahre

Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.
Gurnik S*, Devraj K*, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH*, Reiss Y*.  
Acta Neuropathol. 2016 Mar 1.  *equal contribution

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma.
Scholz A*, Harter PN*, Cremer S*, Yalcin BH, Gurnik S, Yamaji M, Di Tacchio M, Sommer K, Baumgarten P, Bähr O, Steinbach JP, Trojan J, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Braun C, Schittenhelm J, Frueh JT, Ullrich E, Mittelbronn M, Plate KH*, Reiss Y*.
EMBO Mol Med. 2016; 8(1):39-57. *equal contribution

The angiopoietin—tie system: common signaling pathways for angiogenesis, cancer, and inflammation.
Reiss Y, Scholz A, Plate KH.
Springer: Endothel Signal Dev Dis. 2015; 13: 313 – 328. (Review)

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation.
Scholz A, Plate KH, Reiss Y.  
Ann N Y Acad Sci. 2015; 1347:45-51. (Review)

Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells.
Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M.
Cardiovasc Res. 2012 Jun 1;94(3):510-8. Epub 2012 Apr 14.

Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.
Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, Drynski J, Harter PN, Mittelbronn M, Dumont DJ, Plate KH, Reiss Y.
Blood. 2011 Nov 3;118(18):5050-9. Epub 2011 Aug 25.

Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.
Coffelt SB, Chen YY, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M, Lewis CE.
J Immunol. 2011 Apr 1;186(7):4183-90. Epub 2011 Mar 2.

Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.
Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y, Lewis CE.
Cancer Res. 2010 Jul 1;70(13):5270-80. Epub 2010