Pathogenicity of multidrug-resistant Gram-negative bacteria

Research Group Dr. Göttig

Göttig Lab

Our research focuses on antibiotic resistance mechanisms and virulence factors of clinically relevant Gram-negative bacteria. Resistance to antibiotics has dramatically increased in recent years, especially among Gram-negative bacteria like Klebsiella pneumonia, Escherichia coli or Acinetobacter baumannii. Multidrug resistance is often caused by acquisition of bacterial enzymes which are encoded on mobile genetic elements (e.g., plasmid-encoded carbapenemase genes). Highly pathogenic bacteria that are non-susceptible to last line antibiotics like carbapenems or polymyxins pose a major threat to public health. These bacteria cause severe nosocomial infections like sepsis or pneumonia and can be transmitted from patient to patient.

Therefore we are interested in characterizing

  • molecular mechanisms by which Gram-negative bacteria become resistant to carbapenems and colistin
  • the molecular evolution of carbapenemases like the New Delhi metallo-beta-lactamase (NDM)
  • how antibiotic resistance genes can be transmitted by horizontal gene transfer in vivo
  • the impact of carbapenem and colistin resistance on fitness and virulence of Gram-negative bacteria
  • the pathogenicity factor Acinetobacter trimeric autotransporter adhesion of A. baumannii


Group Leader

Dr. med. Dr. rer. physiol. Stephan Göttig

Lab members

Kristina Gerbracht
Emily Huth
Felix Krause
Laura Leukert
Rabea Margies
Larissa Neidert
Sara Riedel-Christ
Lea Schauer
Caroline Sittmann
Julian Sommer
Manuela Tietgen