Pathogenicity of multidrug-resistant Gram-negative bacteria

Research Group Dr. Göttig

Göttig Lab

Our research focuses on antibiotic resistance mechanisms and virulence factors of clinically relevant Gram-negative bacteria. Resistance to antibiotics has dramatically increased in recent years, especially among Gram-negative bacteria like Klebsiella pneumonia, Escherichia coli or Acinetobacter baumannii. Multidrug resistance is often caused by acquisition of bacterial enzymes which are encoded on mobile genetic elements (e.g., plasmid-encoded carbapenemase genes). Highly pathogenic bacteria that are non-susceptible to last line antibiotics like carbapenems or polymyxins pose a major threat to public health. These bacteria cause severe nosocomial infections like sepsis or pneumonia and can be transmitted from patient to patient.

Therefore we are interested in characterizing

  • molecular mechanisms by which Gram-negative bacteria become resistant to carbapenems and colistin
  • the molecular evolution of carbapenemases like the New Delhi metallo-beta-lactamase (NDM)
  • how antibiotic resistance genes can be transmitted by horizontal gene transfer in vivo
  • the impact of carbapenem and colistin resistance on fitness and virulence of Gram-negative bacteria
  • the pathogenicity factor Acinetobacter trimeric autotransporter adhesion of A. baumannii

 

Group Leader

Dr. med. Dr. rer. physiol. Stephan Göttig
stephan.goettig@kgu.de

Lab members

Kristina Gerbracht
Emily Huth
Felix Krause
Laura Leukert
Rabea Margies
Larissa Neidert
Sara Riedel-Christ
Lea Schauer
Caroline Sittmann
Julian Sommer
Manuela Tietgen

 

Funding

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